All bets are off the table when high-dose testosterone and its many metabolites are used illegally, such as with anabolic steroid abuse. Strokes, embolisms, and cardiovascular disease are all more likely, as is sudden death, and liver and kidney disease. 44 In women, acne, irreversible deepening of the voice, baldness, increased facial hair, enlarged sex organs, breast reduction, depression, and infertility have all been reported. In adult men that abuse anabolic steroids, acne, baldness, permanent infertility, gynecomastia, loss of libido, erectile dysfunction, testicle shrinkage, and profuse sweating are all reported side effects. Increased testicular cancer hasn't been reported, though. 45,46
Estrogen dominance is a term coined by hormones expert Dr. John R. Lee, and it describes a condition where a woman (or in this case, man) has more estrogen than progesterone. Even if a man's estrogen levels are low, it is still possible that he will experience symptoms of estrogen dominance. The main cause of estrogen dominance in men is exposure to xenoestrogens and phytoestrogens? which are hormone-mimicking chemicals found in consumer-based products and even in the air we breathe. In addition to environmental factors, other causes of estrogen dominance in men include alcoholism, obesity, chronic stress and glandular dysfunction.