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The adrenal glands are responsible for producing hormones that regulate the amount of sodium and fluid in the body, reports Mayo Clinic. In people with Addison's disease, the adrenal glands do not produce the right amounts of these hormones, resulting in fluid buildup. Too much anti-diuretic hormone also results in fluid buildup, leading to low sodium levels. Anti-diuretic hormone prompts the body to retain water instead of excreting it. Any medication that increases perspiration or urination can also cause sodium levels to drop below normal.