For example, anabolic steroids such as Testosterone have a tendency to promote water retention through their ability to be aromatized into Estrogen via the aromatase enzyme. While such an effect might not be a concern for a strength athlete or a powerlifter (such an effect might even be beneficial or desired in such sports), this is not a desired effect for athletes involved in sports that involve speed and swiftness, such as sprinting. Instead, a sprinter, for example, would more likely opt for an anabolic steroid such as Stanozolol ( Winstrol ) or Oxandrolone ( Anavar ), which are two anabolic steroids unable to convert into Estrogen and therefore the issue of water retention, and therefore the issue of added weight that would slow the athlete down is avoided. Many athletes may also elect to ‘stack’ anabolic steroids in a given cycle (stacking refers to the practice of combining more than one anabolic steroid in a cycle). In the case of cycle stacks, an individual might be able to increase the synergy and synergistic effects between the anabolic steroids to create a highly anabolic environment or to create a stack that might assist the user in favoring certain particular athletic or physique goals. These are some of the major reasons as to why the development of different types of steroids has been done.
Hypercalcemia may develop both spontaneously and as a result of androgen therapy in women with disseminated breast carcinoma. If it develops while on this agent, the drug should be discontinued. Caution is required in administering these agents to patients with cardiac, renal or hepatic disease. Cholestatic jaundice is associated with therapeutic use of anabolic and androgenic steroids. Edema may occur occasionally with or without congestive heart failure. Concomitant administration of adrenal steroids or ACTH may add to the edema. In children, anabolic steroid treatment may accelerate bone maturation without producing compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height. The effect on bone maturation should be monitored by assessing bone age of the wrist and hand every six months. This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.