Overexposure to ethyl acetate may cause irritation of the eyes, nose, and throat. Severe overexposure may cause weakness, drowsiness, and unconsciousness.  Humans exposed to a concentration of 400 ppm in mg/L ethyl acetate for a short time were affected by nose and throat irritation.  Ethyl acetate is an irritant of the conjunctiva and mucous membrane of the respiratory tract . Animal experiments have shown that, at very high concentrations, the ester has central nervous system depressant and lethal effects; at concentrations of 20,000 to 43,000 ppm (–%), there may be pulmonary edema with hemorrhages , symptoms of central nervous system depression, secondary anemia and liver damage . In humans, concentrations of 400 ppm cause irritation of the nose and pharynx ; cases have also been known of irritation of the conjunctiva with temporary opacity of the cornea . In rare cases exposure may cause sensitization of the mucous membrane and eruptions of the skin . The irritant effect of ethyl acetate is weaker than that of propyl acetate or butyl acetate .