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The first major question to be addressed regards how the ethical analysis of risk was understood by the members of the National Commission. The National Commission sat from 1975 to 1978 and issued a total of ten reports on differing aspects of human subjects research. The National Commission's work represents the first sustained in-depth exploration of the moral analysis of risk in research. As such, it has had a lasting influence on research ethics scholarship and federal regulation. Little recognized is the fact that the National Commission's views on risk analysis evolved over its four-year term. Three distinct views on the ethical analysis of risks and potential benefits in research can be found in the National Commission's opus: analysis of entire protocols; analysis of protocols with particular components; and analysis of components.