Correlations between circulating DHEA/DHEAS levels and urticaria and other immune-related disorders has led to proposals for DHEA supplementation. However, clinical trials are largely lacking. 28 , 29 , 30 In 1 study, no effect of DHEA supplementation was found in well-established rheumatoid arthritis. 24 Decreased disease activity was observed in a study of patients with inflammatory bowel disease. However, the study was not placebo controlled. 24 Animal studies of experimental sepsis and trauma have shown DHEA to decrease splenocyte proliferation and increase circulating NK cells and CD8+ lymphocytes; a role in managing critical illness has been suggested as a result. 31
The results showed that heart rate wasn’t affected by either caffeine alone or any combination of caffeine and geranamine. But blood pressure and RPP were higher, depending on the dosage. Specifically, systolic blood pressure rose by 20 percent and diastolic blood pressure went up 17 percent, along with a 9 percent increase in RPP, with the combination of 250 milligrams of caffeine and 75 milligrams of geranamine an hour after the subjects took it. The catecholamines, epinephrine and norepinephrine, were not affected. What’s interesting about this is that unlike ephedrine, the catecholamines were not involved in the rise in blood pressure. Nor was the heart rate affected. So what did cause blood pressure to go up with the greatest dose? That remains for future research to determine.