Antiandrogens like spironolactone are male-specific teratogens which can feminize male fetuses due to their antiandrogen effects (see below ).    For this reason, it is recommended that antiandrogens only be used to treat women who are of reproductive age in conjunction with adequate contraception.    Oral contraceptives, which contain an estrogen and a progestin , are typically used for this purpose.  Moreover, oral contraceptives themselves are functional antiandrogens and are independently effective in the treatment of androgen-dependent skin and hair conditions, and hence can significantly augment the effectiveness of antiandrogens in the treatment of such conditions.  
This remarkable extract of the Australian plant Melaleuca alternifolia has powerful natural antifungal properties. Douching daily with a 1 percent solution in water (or, once a week, soaking a tampon into such a solution and inserting it into the vagina as a pessary, leaving it there for no more than 24 hours) can be very helpful as a natural treatment for vaginitis or cervicitis. This approach is useful whether the cause is candida or trichomonas. Tea tree oil can also be used as a gargle or mouthwash (one drop in a tumbler of water) for oral thrush, or applied directly onto the skin as an ointment. It is somewhat irritating to the skin if used neat as an oil, but there are many products with a 15 percent tea-tree-oil content that are relatively nonirritating and are great antifungal supplements.
Stephan Bonnar and Josh Barnett , mixed martial arts (MMA) fighters from the UFC and PRIDE Fighting Championships , have also tested positive for the banned substance.  After the World Extreme Cagefighting show on January 20, 2006 Muay Thai turned MMA fighter Kit Cope also tested positive for boldenone.  Following the Strikeforce card on June 22, 2007 former PRIDE and UFC fighter Phil Baroni tested positive for boldenone, as well as stanozolol .  At a K-1 WGP event in Las Vegas on August 17, 2007 two fighters, Rickard Nordstrand and Zabit Samedov , both tested positive for boldenone.  Alexandre Franca Nogueira tested positive for boldenone in July 2008.