Biosynthesis of testosterone

The rate of turnover in a metabolic pathway, otherwise known as the metabolic flux , is regulated based on the stoichiometric reaction model, the utilization rate of metabolites, and the translocation pace of molecules across the lipid bilayer . [20] The regulation methods are based on experiments involving 13C-labeling , which is then analyzed by Nuclear Magnetic Resonance (NMR) or gas chromatography-mass spectrometry (GC-MS) -derived mass compositions. The aforementioned techniques synthesize a statistical interpretation of mass distribution in proteinogenic amino acids to the catalytic activities of enzymes in a cell. [21]

This enzyme is one of the most complex in our bodies.   It consists of three polypeptide chains, two of which are identical to each other.   The third is a very small polypeptide called acyl carrier protein (ACP), which contains a phosphopantetheine group (derived from the vitamin panthothenic acid) that is identical to the one in Coenzyme A.   The other two polypeptides have 7 different enzymatic activities.   The enzyme works by first mobilizing malonyl CoA and acetyl CoA (attaching them to ACP).   Then the enzyme begins a cycle of reactions in which a fatty acid grows from ACP.   At the end of each cycle the growing fatty acid is 2 carbons long.   When the fatty acid has reached 16 carbons in length, it is cleaved from the ACP.  

Biosynthesis of testosterone

biosynthesis of testosterone


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